familial expansile osteolysis

Epidemiology

rare

Pathology

• bone disorder characterized by focal areas of increased bone remodeling

Genetics

• autosomal dominant
• associated with defects in TNFRSF11A are the cause of

Clinical manifestations

• often associated with early onset deafness & loss of dentition

Radiology

• osteolytic lesions develop usually in the long bones during early adulthood

More general terms

• inherited disorder of osteolysis

Database

• OMIM: https://mirror.omim.org/entry/174810