early onset hypertension with severe exacerbation in pregnancy
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Pathology
- suppression of aldosterone secretion
- mutant form of receptor is associated with activation by progesterone[2]
Genetics
- autosomal dominant
- associated with defects in NR3C2 are a cause of
Clinical manifestations
- onset of severe hypertension before the age of 20
- severe exacerbation of hypertension in pregnant women
More general terms
References
- ↑ OMIM https://mirror.omim.org/entry/605115
- ↑ 2.0 2.1 Geller DS et al Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science 289:119, 2000 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10884226