bacteriophage
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Introduction
A virus with a specific affinity for bacteria.
They contain DNA or RNA (but never both).
They are associated with all groups of bacteria.
Their structure varies from simple filamentous to relatively complex with contractile tails.
They are generally named after the bacterial species for which they are specific.
Pathology
- > 2000 specific bacteriophages infecting gut bacteria are associated human chronic diseases, particularly Parkinson disease & obesity[3]
- many of the viral sequences are integrated into human chromosomal DNA or in circular episomes[3]
Pharmacology
- 3 bioengineered bacteriophages IV every 12 hours for 32 weeks cleared an antibiotic-resistant Mycobacterium abscessus infection from serum & sputum in a patient with cystic fibrosis[2]
More general terms
References
- ↑ Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999
- ↑ 2.0 2.1 Dedrick RM, Guerrero-Bustamante CA, Garlena RA et al Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus. Nature Medicine, 25, 730-733, 2019 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30948168 https://www.nature.com/articles/s41591-019-0437-z
Schmidt C Phage therapy's latest makeover. Nature Biotechnology (2019). May 8 Not indexed in PubMed https://www.nature.com/articles/s41587-019-0133-z - ↑ 3.0 3.1 3.2 Tisza MJ, Buck CB. A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases. Proc Natl Acad Sci U S A 2021 Jun 8; 118:e2023202118. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34083435 PMCID: PMC8201803 Free PMC article https://www.pnas.org/content/118/23/e2023202118