Fusarium
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Introduction
Presumptively classified as Hypomycetes.
Pathology
- Fusarium keratitis associated with contact lens solution, ReNu with MoistureLoc[2]
- human pathogen in immunocompromised hosts
- Fusarium skin lesions in immunosuppressed patients are almost always associated with disseminated myocosis[1]
Clinical manifestations
Laboratory
- may appear identical to Aspergillus in tissue smears
- may be cultured from blood or skin biopsy material
- Fusarium IgE in serum
Management
- amphotericin B 1.0-1.5 mg/kg/day IV
- may be highly resistant to amphotericin B
- liposomal amphotericin B + terbinafine has been used[3]
More general terms
More specific terms
References
- ↑ 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 15, American College of Physicians, Philadelphia 1998, 2009
- ↑ 2.0 2.1 Chang DC et al, Multistate outbreak of Fusarium keratitis associated with use of contact lens solution. JAMA 2006, 296:953 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/16926355 <Internet> http://jama.ama-assn.org/cgi/content/full/296/953
- ↑ 3.0 3.1 Neuburger S et al Successful salvage treatment of disseminated cutaneous fusariosis with liposomal amphotericin B and terbinafine after allogeneic stem cell transplantation Transpl Infect Dis 2008 10(4):290-3 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18194367