immunoglobulin-G4 (IgG4)

Function

• generally binds to polysaccharid antigens
• does NOT bind complement

Pathology

• major subclass of antibasement membrane antibody in bullous pemphigoid
• IgG4 disease

Pharmacology

• natalizumab is a recombinant humanized IgG4-kappa monoclonal antibody

Laboratory

• IgG4 in serum increased in autoimmune pancreatitis & pancreatic cancer (IgG4 disease)
• IgG4 Ag in tissue

More general terms

• immunoglobulin-G (IgG, Cuvitru)

Additional terms

• IgG4 disease
• IgG4 in serum