glucose-1-phosphate (Cori ester)

Biochemistry

• formed during glycogenolysis by the action of glycogen phosphorylase
  • enzyme: glycogen phosphorylase
  • substrates: glycogen + phosphate
  • product: glucose-1-phosphate
• converted to glucose-6-phosphate by phosphoglucomutase in 1st step of glycolysis
  • enzyme: phosphoglucomutase
  • substrate: glucose-1-phosphate
  • product: glucose-6-phosphate
• metabolized by UDP-glucose pyrophosphorylase to form UDP-glucose
  • enzyme: UDP-glucose pyrophosphorylase
  • substrate: glucose-1-phosphate
  • product: UDP-glucose
• the UDP-glucose can then return glucose to glycogen via glycogen synthase
  • enzyme: glycogen synthase
  • substrates: UDP-glucose + glycogen
  • products: glycogen(+1) + UDP

More general terms

• glucose phosphate

Additional terms

• glycolytic pathway (glycolysis, Embden Myerhof pathway)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=439165
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=449515