2,3-diphosphoglycerate (2,3-DPG); 2,3-bisphosphoglycerate (2,3-BPG)

Introduction

Levels regulate affinity of hemoglobin for oxygen; greater levels of 2,3-DPG results in diminished hemoglobin oxygen affinity. 2,3-DPG may lower hemoglobin oxygen affinity by a factor of 26.

Formation of 2,3-DPG reversibly catalyzed by bisphosphoglycerate mutase.

More general terms

• diphosphoglycerate
• carboxylate

Additional terms

• bisphosphoglycerate mutase (BPGM)
• Rappaport Luebering pathway

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=61
• Kegg: http://www.genome.jp/dbget-bin/www_bget?