Rappaport Luebering pathway

Introduction

Pathway from 1,3-diphosphoglycerate (1,3-DPG) to 3-phospho- glycerate (3-PG) through 2,3-diphosphoglycerate (2,3-DPG), presumably to generate 2,3-DPG for regulation of hemoglobin oxygen affinity in erythrocytes. The pathway, a detour off the pathway of glycolysis, comes at a cost, sacrificing production of ATP in the conversion of 1,3-DPG to 3-PG.

         2,3-DPG mutase            2,3-DPG phosphatase
1,3-DPG  -------------->  2,3-DPG  ------------------->  3-PG

More general terms

• molecular pathway

Additional terms

• 1,3-diphosphoglycerate
• 2,3-di(bis)phosphoglycerate mutase/phosphatase
• 2,3-diphosphoglycerate (2,3-DPG); 2,3-bisphosphoglycerate (2,3-BPG)
• 3-phosphoglycerate