homogentisate

Introduction

Homogentisate is an intermediate in the oxidation of tyrosine & phenylalanine to acetoacetate & fumarate. It is formed from p-hydroxyphenyl pyruvate by the action of p-hydroxyphenylpyruvate hydroxylase. Homogentisate oxidase cleaves homogentisate to 4-maleylacetoacetate.

More general terms

• phenol
• carboxylate

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=780