tolazoline (Priscoline, Arterodyl)

Introduction

Tradename: Priscoline.

Indications

• persistent fetal circulation

Dosage

• load 1-2 mg/kg IV over 10 min, then
• infusion 1-2 mg/kg/hr.

Injection: 25 mg/mL (10 mL).

Adverse effects

• common (> 10%)
  • GI bleeding, abdominal pain, hypochloremic acidosis, hypotension, acute renal failure, oliguria, thrombocytopenia, burning at site of injection
• less common (1-10%)
  • nausea, diarrhea, increased pilomotor activity, peripheral vasodilation, tachycardia
• uncommon (< 1%)
  • mydriasis, hypertension, tachycardia, arrhythmias, agranulocytosis, pancytopenia, increased secretions, pulmonary hemorrhage

• drug adverse effects of antihypertensive agents

More general terms

• imidazole; glyoxaline; 1,3-diazole; iminazole
• alpha adrenergic receptor antagonist

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6048
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5504
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=562944