glycinexylidide (GX)

Introduction

Alias GX.

Hepatic metabolites of lidocaine include GX & monoethyl- glycinexylidide (MEGX). Renal failure leads to accumulation of GX & MEGX which have little pharmacologic activity, but can produce significant neurotoxicity. Myocardial infarction, CHF, or liver disease may also prolong 1/2life of glycinexylidide.

Drug interactions

• propranolol, cimetidine increase 1/2life of glycinexylidide

More general terms

• amine
• carboxylate
• pharmacologic metabolite

Additional terms

• lidocaine (Xylocaine)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=87833