cefmetazole (Zefazone)

Introduction

Tradename: Zefazone. 2nd generation cephalosporin.

Dosage

2 g IV every 6-12 hours

Antimicrobial activity

Gram positive

• Streptococcus
  • Streptococcus group A
  • Streptococcus group B
  • Streptococcus group C
  • Streptococcus group G
  • Streptococcus pneumonia
  • Streptococcus viridans, milleri
• Staphylococcus aureus (MSSA)
• Staphylococcus epidermidis (+/-)

Gram negative

• Neisseria gonorrhoeae
• Neisseria meningitidis
• Moraxella catarrhalis
• Haemophilus influenzae
• Escherichia coli
• Klebsiella species
• Salmonella species
• Shigella species
• Proteus mirabilis
• Proteus vulgaris
• Providencia species
• Morganella species
• Citrobacter species (+/-)
• Aeromonas species (+/-)

Anaerobes

• Bacteroides fragilis
• Bacteroides melaninogenicus
• Clostridium species
• Peptostreptococcus species

Adverse effects

• bleeding secondary to coagulopathy (in elderly)

• drug adverse effects of cephalosporins

Drug interactions

• coadministration with alcohol may produce a disulfiram-like reaction
• cefmetazole may enhance the effect of warfarin

• drug interaction(s) anticonvulsants with anti-bacterial agents
• drug interaction(s) of antibiotics with warfarin

More general terms

• cephalosporin, 2nd generation

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=42008
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2625
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=42009