loracarbef (Lorabid)

Introduction

Tradename: Lorabid. 2nd generation cephalosporin.

Indications

• bacterial infections due to susceptible organisms
  • acute otitis media
  • upper respiratory tract infections
    • tonsillitis
  • lower respiratory tract infections
    • bronchitis
    • pneumomia
  • chronic pyelonephritis
  • skin or soft tissue infection

Dosage

200-400 mg PO BID

Children: Otitis 30 mg/kg/day divided BID. Other 15 mg/kg/day.

Tabs: 200 mg, Suspension: 100 mg/5 mL.

Antimicrobial activity

Gram positive

• Streptococcus
  • Streptococcus group A
  • Streptococcus group B
  • Streptococcus group C
  • Streptococcus group G
• Streptococcus pneumonia
• Streptococcus viridans, milleri
• Staphylococcus aureus (MSSA)
• Staphylococcus epidermidis (+/-)

Gram negative

• Neisseria gonorrhoeae
• Neisseria meningitidis
• Moraxella catarrhalis
• Haemophilus influenzae
• Escherichia coli
• Klebsiella species
• Proteus mirabilis

More general terms

• cephalosporin, 2nd generation

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60746
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3956
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5284585
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5284584