cefoperazone (Cefobid)

Introduction

Tradename: Cefobid. 3rd generation cephalosporin.

Dosage

2-4 g IV every 12 hours

Antimicrobial activity

Gram positive

• Streptococcus
  • Streptococcus group A
  • Streptococcus group B
  • Streptococcus group C
  • Streptococcus group G
  • Streptococcus pneumonia
  • Streptococcus viridans, milleri
  • Enterococcus faecalis
• Staphylococcus aureus (MRSA)
• Staphylococcus epidermidis (+/-)

Gram negative

• Neisseria gonorrhoeae
• Neisseria meningitidis
• Moraxella catarrhalis
• Haemophilus influenzae
• Escherichia coli
• Klebsiella species
• Enterobacter species
• Serratia species
• Salmonella species
• Shigella species
• Proteus mirabilis
• Proteus vulgaris
• Providencia species
• Morganella species
• Citrobacter species
• Aeromonas species
• Pseudomonas aeruginosa
• Pseudomonas cepacia
• Xanthomonas maltophilia (+/-)
• Yersinia enterocolitica
• Pasteurella multocida

Anaerobes

• Bacteroides melaninogenicus (+/-)
• Clostridium species
• Peptostreptococcus species

Adverse effects

• bleeding secondary to coagulopathy (in elderly)
• increased serum transaminases (ALT, AST)
• eosinophilia
• positive directs Coomb's test may occur

• drug adverse effects of cephalosporins

Drug interactions

• coadministration with alcohol may produce a disulfiram-like reaction
• cefoperazone may enhance the effect of warfarin

• drug interaction(s) anticonvulsants with anti-bacterial agents
• drug interaction(s) of antibiotics with warfarin

Laboratory

• specimen:
  • serum
  • keep specimen on ice-water
  • centrifuge at 4 degrees C
  • remove cells as soon as possible
  • freeze at -70 degrees C until assayed
• methods: HPLC, MB

More general terms

• cephalosporin, 3rd generation

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=44185
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=44187
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2630
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3033223
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=44186
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3085940