mezlocillin (Mezlin, Baypen)

Introduction

Tradename: Mezlin. 4th generation penicillin.

Indications

• bacterial infections due to susceptible organisms
  • intra-abdominal infections
    • cholangitis
  • urogenital infection
    • gonorrhea
  • anaerobic infections
    • brain abscess
  • skin or soft tissue infection
  • infectious arthritis, osteomyeltitis

Dosage

3-4 g IV/IM every 4-6 hours

Dosage adjustment in renal failure

Table

creatinine clearance	dosage
> 50-90 mL/min	every 4-6 hours
10-50 mL/min	every 6-8 hours
< 10 mL/min*	every 8 hours

* no additional dosing for hemodialysis

Pharmacokinetics

• elimination 1/2life 1.1 hours (2.6-5.4 hours ESRD)

elimination via kidney

Antimicrobial activity

Gram positive

• Streptococcus
  • Streptococcus group A
  • Streptococcus group B
  • Streptococcus group C
  • Streptococcus group G
• Streptococcus pneumonia
• Streptococcus viridans, milleri
• Enterococcus faecalis (+/-)
• Enterococcus faecium (+/-)
• Listeria monocytogenes

Gram negative

• Neisseria gonorrhoeae
• Neisseria meningitidis
• Haemophilus influenzae (+/-)
• Escherichia coli
• Klebsiella species
• Enterobacter species
• Serratia species
• Salmonella species
• Shigella species
• Proteus mirabilis
• Proteus vulgaris
• Providencia species
• Morganella species
• Citrobacter species
• Aeromonas species
• Pseudomonas aeruginosa
• Xanthomonas maltophilia (+/-)
• Yersinia enterocolitica
• Pasteurella multocida

Anaerobes

• Bacteroides fragilis
• Bacteroides melaninogenicus
• Clostridium difficile
• Clostridium species
• Peptostreptococcus species

More general terms

• 4th generation penicillin (extended-spectrum)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=107796
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=656511
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=40027