clotrimazole (Lotrimin, Mycelex, Gyne-Lotrimin, Desenex)

Introduction

Oral agent: Tradename: Mycelex.

Indications

• oropharyngeal candidiasis
• cutaneous fungal infection
  • Tinea pedis, Tinea cruris, Tinea corporis, Tinea versicolor
  • paronychia
• Candida vulvovaginosis
• diaper rash

Dosage

Lozenge 5 times/day for 14 days

Lozenges: 10 mg.

Topical agent: Tradenames: Lotrimin, Mycelex.

1% cream/solution/lotion to area BID.

Monitor

• baseline liver function tests (LFTs)
• repeat LFTs in one month

Adverse effects

• common (> 10%)
  • abnormal liver function tests
• less common (1-10%)
  • nausea/vomiting, mild burning, irritation, stinging to skin or vaginal area

Drug interactions

• decreases metabolism of cisapride possibly leading to prolongation of the QT interval & fatal tachyarrhythmias

• drug interaction(s) of antibiotics with warfarin

Mechanism of action

• alteration of the cell membrane permeability via binding of phospholipids
• fungistatic

More general terms

• antifungal agent
• imidazole; glyoxaline; 1,3-diazole; iminazole

Component of

• betamethasone/clotrimazole/gentamicin
• betamethasone/clotrimazole (Lotrisone)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2812