fludrocortisone (Florinef)

Introduction

Tradename Florinef.

Indications

• Addison's disease
• replacement therapy for adrenal insufficiency
• treatment of salt-losing forms of congenital adrenogenital syndrome
• orthostatic hypotension

Adults 0.05-0.2 mg PO QD.

Infants & children: 0.05-0.1 PO QD

Tabs: 0.1 mg.

Adverse effects

• most common (1-10%)
  • hypertension, dizziness, edema, congestive heart failure, convulsions, headache, acne, rash, hypokalemic alkalosis, growth suppression, hyperglycemia, suppression of hypothalamic-pituitary-adrenal axis, peptic ulcer, bruising, muscle weakness, cataracts

Drug interactions

• aminoglutethimide
• anticholinesterases
• barbiturates
• carbamazepine
• phenytoin
• rifampin
• vaccines (live virus)

Laboratory

• fludrocortisone in serum/plasma
• fludrocortisone in urine

Mechanism of action

pure mineralocorticoid

More general terms

• mineralocorticoid

Additional terms

• Addison's disease (primary adrenal failure)
• orthostatic hypotension; Bradbury-Eggleston Syndrome; postural orthostatic tachycardia syndrome (POTS)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=31378
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=541123
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3370