masoprocol; nordihydroguaiaretic acid; NDGA (Actinex)

Introduction

Derived from plant Larrea divaricata

Tradename: Actinex.

Dosage

Actinic keratosis: apply BID for about 1 month Cream 10%.

Adverse effects

• contact sensitization (9%)
• redness, flaking, pruritus are common

Mechanism of action

• 5-lipoxygenase inhibitor
• antitumor activity No comparative double-blind studies with 5-fluorouracil

More general terms

• polyphenol
• lipoxygenase inhibitor
• topical agent

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=71398
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=688036
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4534