meclofenoxate (Centrophenoxine, Lucidril)

Introduction

Tradenames: Centrophenoxine, Lucidril.

Uses

• treatment of symptoms of senile dementia & Alzheimer's Disease
• used off-label as a as a nootropic, often combined with a racetam drug such as piracetam

Contraindications

• severely high blood pressure
• epilepsy, seizures

Dosage

• 250-3,000 mg/day taken in 1 or more doses

Adverse effects

• generally considered safe
• possible side effects may include nausea or mild dizziness
• large doses may cause tight jaw clenching.

Mechanism of action

• contains two biochemicals:
  • dimethylaminoethanol (DMAE)
  • parachlorophenoxyacetate (pCPA)
    • synthetic compound that resembles a variety of plant hormones called auxins
• see dimethylaminoethanol (DMAE)

More general terms

• glycolate
• nootropic agent
• neuroprotective agent

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4039
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=19379