aluminum carbonate (Basaljel)

Introduction

Tradename: Basaljel.

Indications

• symptomatic treatment of dyspepsia, peptic ulcer, GERD, hiatal hernia
• stress ulcer prophylaxis
• hyperphosphatemia

Dosage

1-3 capsules 1-3 hours after meals & QHS PRN

Pharmacokinetics

• usual duration of action is 20-60 minutes if taken after meals
• effects may persist for up to 3 hours

Adverse effects

• constipation
• decrease in GI motility
• long term use in patients with renal failure may result in aluminum toxicity

• drug adverse effects of antacid(s)

Drug interactions

• decreased absorption of many medications

• drug interaction(s) of iron supplements in combination with antacids
• drug interaction(s) of beta-adrenergic receptor antagonists with aluminum carbonate

Mechanism of action

• increased pH of gastric secretions
• aluminum binds phosphate in food within the intestine

More general terms

• salt
• antacid

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=107907
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3016817