perindopril (Aceon, Coversyl)

Introduction

Tradename: Aceon.

Indications

• hypertension
• heart failure
• diabetic nephropathy, nondiabetic proteinuric nephropathy
• atherosclerosis
  • myocardial infarction

Dosage

• usual dose is 4-8 mg PO QD
• higher doses are not much more effective

Tabs: 2, 4 & 8 mg.

Mechanism of action

• see ACE inhibitor
• may prevent progression of atherosclerosis (8 mg/day)
  • treating 50 patients for 4 years seems to prevent 1 major cardiovascular event

Clinical trials

• EUROPA trial

More general terms

• angiotensin-converting enzyme (ACE) inhibitor

Additional terms

• EURopean trial On reduction of cardiac events with Perinopril in stable coronary Artery disease (EUROPA) trial

Component of

• amlodipine/arginine/perindopril

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=107807
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60183
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60184
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=441313