flutamide (Eulexin, Niftholide)
Jump to navigation
Jump to search
Introduction
Tradename: Eulexin.
Indications
- used in combination with LHRH agonist for treatment of metastatic prostate cancer
- hair growth restoration ?
Contraindications
- Pregnancy category X
- significant liver disease
Dosage
Capsule: 125 mg
Pharmacokinetics
- Not eliminated by hemodialysis
Monitor
- serum ALT & serum AST baseline, monthly for 4 months, then periodically (every 6 months)[2][3]; discontinue if serum AST or serum ALT > 3x upper limit of normal despite recheck
Adverse effects
- common (> 10%)
- less common (1-10%)
- anorexia, gynecomastia, numbness in extremities
- uncommon (< 1%)
Mechanism of action
More general terms
Additional terms
References
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
- ↑ Jump up to: 2.0 2.1 deprecated reference
- ↑ Jump up to: 3.0 3.1 Prescriber's Letter 17(7): 2010 Recommended Lab Monitoring for Common Medications Liver Function Test Scheduling Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260704&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ PubMed Health: Flutamide http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001014/