LY295427
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Introduction
Synthetic sterol.
Mechanism of action
- reduces plasma cholesterol by increasing expression of LDL receptor
- reverses oxysterol-induced suppression of sterol regulatory element binding protein (SREBP) processing
More general terms
Additional terms
- low-density lipoprotein receptor; LDL receptor; apoB/E receptor (LDLR)
- sterol regulatory element binding protein (SREBP)
References
- ↑ Janowskii et al, The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. J Biol Chem 276:45408, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11577112