enfuvirtide (Fuzeon)
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Indications
Contraindications
Dosage
Adverse effects
- injection site reactions routine (painful skin nodules)
- hypersensitivity (respiratory distress)
- pneumonia
Mechanism of action
- fusion inhibitor
- prevents HIV from entering immune cells
- addition of enfuvirtide to optimized anti-retoviral regimen results in significant declin in viral load
Notes
cost $20,000/year (2003)
More general terms
References
- ↑ Info: 866-694-6670
- ↑ Prescriber's Letter 10(4):23 2003
- ↑ Journal Watch 23(13):104-5, 2003 Lalezari P et al, NEJM 348(22):2175, 2003 Lazzarin A et al, NEJM 348(22):2175, 2003 Tshimi KT & Carpenter CCJ, NEJM 348(22):2249, 2003
- ↑ 4.0 4.1 Zuger A Use of Antiretroviral Drugs in Pregnancy. Physician's First Watch, April 22, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission. Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States. 2014. AIDSinfo. Clinical Guidelines Portal. March 28, 2014. http://aidsinfo.nih.gov/Guidelines/HTML/3/perinatal-guidelines/0 (corresponding NGC guideline withdrawn March 2016) - ↑ Department of Veterans Affairs, VA National Formulary