fluoride toxicity

Etiology

• pesticide exposure
• dental fluorosis

Pathology

• ingestion of 2 g of NaFl is lethal
• precipitation of Ca+2 causing hypocalcemia & tetany
• fluoride inhibits carbohydrate metabolism
• chronic ingestion mottles dental enamel

Clinical manifestations

• nausea and vomiting (corrosive vomitus)
• abdominal pain
• diarrhea
• hypertension
• manifestations of hypocalcemia

Laboratory

• hyperglycemia
• prolonged blood clotting time

Radiology

osteosclerosis

More general terms

• toxicity; poisoning; overdose

More specific terms

• dental fluorosis

Additional terms

• hypocalcemia