ependymoma

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Introduction

corresponds to WHO grade II.

Etiology

Epidemiology

  • 2% of brain tumors
  • ~10% of childhood brain tumors are ependymomas
  • most ependymomas occur in children
    • adults are generally 30-40 years of age[4]

Pathology

Microscopic pathology

Genetics

Radiology

Management

Prognosis:

Comparative biology

More general terms

More specific terms

References

  1. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 2398
  2. Harrison's Online, Chapter 370, McGraw-Hill, 2002
  3. WHO Classification Tumours of the Nervous System. Kleihues & Cavenee eds. IARC Press 2000
  4. 4.0 4.1 4.2 4.3 Medical Knowledge Self Assessment Program (MKSAP) 16 American College of Physicians, Philadelphia 2012
  5. 5.0 5.1 Mack SC, Witt H, Piro RM, Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature. 2014 Feb 27;506(7489):445-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24553142 Free PMC Article
  6. 6.0 6.1 Rapaport L Common Diabetes Drug Shrinks Brain Tumors in Mice. Medscape. November 03, 2021 https://www.medscape.com/viewarticle/962161
    Panwalkar P, Tamrazi B, Dang D et al Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas. Sci Transl Med. 2021 Oct 13;13(615):eabf7860 PMID: https://www.ncbi.nlm.nih.gov/pubmed/34613815 https://www.science.org/doi/10.1126/scitranslmed.abc0497

Patient information

ependymoma patient information

Database