pilomyxoid astrocytoma
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Introduction
more aggressive variant of pilocytic astrocytoma vs. separate entity.
Microscopic pathology
- similar to pilocytic astrocytoma but more monomorphous and more myxoid[1]
- no Rosenthal fibers (18/18 cases)[1]
- some features of myxopapillary ependymoma[2] (cells converging on small blood vessels pseudorossette-like)
- bipolar cells with elongated processes
- apical surfaces with microvilli, cytoplasmic blebs, rare cilia
- vesicles & coated pits seen
- occasional synaptoid complex[2] Immunohistochemistry (3 cases)[2]:
- GFAP +
- vimentin +
- S 100 +
- synaptophysin +
- chromogranin -
More general terms
References
- ↑ Jump up to: 1.0 1.1 1.2 Tihan et al. J Neuropathol Exp Neurol. 58:1061-8, 1999
- ↑ Jump up to: 2.0 2.1 2.2 2.3 Fuller et al. Clin Neuropath.20:256-62, 2001