pilomyxoid astrocytoma
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Introduction
more aggressive variant of pilocytic astrocytoma vs. separate entity.
Microscopic pathology
- similar to pilocytic astrocytoma but more monomorphous and more myxoid[1]
- no Rosenthal fibers (18/18 cases)[1]
- some features of myxopapillary ependymoma[2] (cells converging on small blood vessels pseudorossette-like)
- bipolar cells with elongated processes
- apical surfaces with microvilli, cytoplasmic blebs, rare cilia
- vesicles & coated pits seen
- occasional synaptoid complex[2] Immunohistochemistry (3 cases)[2]:
- GFAP +
- vimentin +
- S 100 +
- synaptophysin +
- chromogranin -