fas/Apo-1 gene (CD95 gene, murine lpr gene)

Introduction

The fas/Apo-1/CD95 gene is the murine lpr gene. A genetic deficiency in lpr or gld (murine FasL gene) causes a lymphoproliferation & autoimmune disease that resembles Lupus However, humans with Lupus do not have mutations in the fas gene. The fas/apo1 gene contains 3 transcriptional initiation sites, a GC-rich element (CpG island), & consensus sequences for binding of AP1, GF-1, NY-Y, CP-2, EBP20 & c-myb, but lacks canonical TATA & CCAAT boxes.

More general terms

• unclassified gene

Additional terms

• fasL gene