resistin; adipose tissue-specific secretory factor; ADSF; C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; cysteine-rich secreted protein A12-alpha-like 2; cysteine-rich secreted protein FIZZ3 (RETN, FIZZ3, HXCP1, RSTN, UNQ407/PRO1199)

Function

• adipokine that seems to suppress the ability of insulin to stimulate glucose uptake into adipocytes

Compartment

secreted, plasma

Expression

• secreted by adipocytes
• thiazolidinediones, i.e. glitazone, down-regulate resistin gene expression

Pathology

• contributes to insulin resistance
• potentially links obesity to diabetes mellitus type 2
• higher serum levels are observed in humans with diabetes mellitus type 2

Laboratory

• resistin in serum/plasma

Comparative biology

• injection into mice increases serum glucose

More general terms

• adipokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56729
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56729
• OMIM: https://mirror.omim.org/entry/605565
• UniProt: http://www.uniprot.org/uniprot/Q9HD89.html