protein NOV homolog; NovH; nephroblastoma overexpressed gene protein homolog (NOV, CCN3, IGFBP9, NOVH)

Function

• immediate-early protein
• role in cell growth regulation (putative)
• interacts with FBLN1

Structure

• belongs to the CCN family
• contains 1 CTCK (C-terminal cystine knot-like) domain
• similarity to insulin like growth factor binding proteins
• contains 1 IGFBP N-terminal domain
• contains 1 TSP type-1 domain
• contains 1 VWFC domain

Compartment

secreted

Pathology

• increased expression in
  • Wilms tumor of the stromal type
  • avian nephroblastoma

More general terms

• growth factor
• proto oncogene protein
• glycoprotein
• secreted protein

Component of

• guaifenesin/nov protein/pseudoephedrine
• glycerol/naphazoline/nov protein
• dextromethorphan/guaifenesin/nov protein/pseudoephedrine
• chlorcyclizine/nov protein/phenylephrine
• aspirin/citrate/diphenhydramine/nov protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4856
• OMIM: https://mirror.omim.org/entry/164958
• UniProt: http://www.uniprot.org/uniprot/P48745.html