ELAV-like protein 3; Hu-antigen C; HuC; paraneoplastic cerebellar degeneration-associated antigen; paraneoplastic limbic encephalitis antigen 21 (ELAVL3, HUC, PLE21)

Function

• RNA-binding protein
• may be involved in neuronal differentiation & maintenance
• binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA
• may also bind poly-A tracts via RRM 3

Structure

• RRM 1 & RRM 2 bind cooperatively to AU-rich sequences in target mRNAs
• RRM 3 binds to poly-A mRNA sequences
• belongs to the RRM elav family
• contains 3 RRM domain (RNA recognition motif)s

Alternative splicing

named isoforms=2

Expression

brain specific

Pathology

• autoantigen of paraneoplastic syndromes (anti-Hu antibody)

More general terms

• RNA-binding protein
• antigen

Additional terms

• anti-Hu antibody (type-1 ANNA)
• cerebellar degeneration related protein
• paraneoplastic cerebellar degeneration

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1995
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1995
• OMIM: https://mirror.omim.org/entry/603458
• UniProt: http://www.uniprot.org/uniprot/Q14576.html