Islet cell autoantigen 1; 69 kD islet cell autoantigen; ICA69; Islet cell autoantigen p69; ICAp69; p69 (ICA1)

Function

• may play a role in neurotransmitter secretion

Structure

contains 1 AH domain

Compartment

• cytoplasm, cytosol
• Golgi membrane
• peripheral membrane protein (putative)
• cytoplasmic vesicle, secretory vesicle membrane
• peripheral membrane protein (putative)
• cytoplasmic vesicle, secretory vesicle
• synaptic vesicle membrane
• predominantly cytosolic
• also exists as a membrane-bound form which has been found associated with synaptic vesicles & also with the Golgi complex & immature secretory granules

Expression

• expressed abundantly in pancreas, heart & brain with low levels of expression in lung, kidney, liver & thyroid

Pathology

• autoantigen in insulin-dependent diabetes mellitus

More general terms

• other protein
• antigen

Database

• UniProt: http://www.uniprot.org/uniprot/Q05084.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3382
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3382
• OMIM: https://mirror.omim.org/entry/147625