mitochondrial brown fat uncoupling protein 1; UCP 1; thermogenin (UCP1, SLC25A7)

Function

• mitochondrial transporter protein that creates proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis
• as a result, energy is dissipated in the form of heat
• acts as a dimer forming a proton channel

Structure

• belongs to the mitochondrial carrier family
• contains 3 solcar repeats

Compartment

mitochondrial inner membrane

Expression

brown adipose tissue

Polymorphism

• the Thr-64 polymorphism is associated with an increased waist-to-hip ratio
• the Leu-229 polymorphism is associated with susceptibility to diabetes mellitus type 2

More general terms

• solute carrier family 25 (SLC25, SLC25A)
• uncoupling protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7350
• OMIM: https://mirror.omim.org/entry/113730
• UniProt: http://www.uniprot.org/uniprot/P25874.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7350