CNGA2/CNGA4/CNGB1b complex

Function

• forms the cyclic nucleotide-gated cation channel of olfactory sensory neurons
• Ca+2-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif of CNGA4 & preferably binds to the channel in the closed state
• inhibition by PIP3 of the CNG channel probably occurs via CGNA2 binding

Structure

• subunits: CNGA2, CNGA4, CNGB1b

More general terms

• molecular complex
• cyclic nucleotide-gated cation channel