ribonuclease H2 (RNase H2)

Function

• endonuclease that specifically degrades the RNA of RNA:DNA hybrids
• DNA replication
• mediates the removal of lagging-strand Okazaki fragment RNA primers during DNA replication (putative)
• mediates the excision of single ribonucleotides from DNA:RNA duplexes.
• endonucleolytic cleavage to 5'-phosphomonoester
• heterotrimer composed of the
  • RNASEH2A (catalytic)
  • RNASEH2B, RNASEH2C (regulatory)

Compartment

nucleus

More general terms

• molecular complex
• ribonuclease (RNase)