aquaporin-10; AQP-10; small intestine aquaporin (AQP10)

Function

• forms a water channel. not permeable to urea & glycerol
• may contribute to water transport in the upper portion of small intestine

Structure

• aquaporins contain two tandem repeats each containing 3 membrane-spanning domains & a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)

belongs to the MIP/aquaporin (TC 1.A.8) family

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed exclusively in duodenum & jejunum
• highest expression in absorptive epithelial cells at the tips of villi in the jejunum

More general terms

• transmembrane 5c protein
• aquaporin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=89872
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:89872
• OMIM: https://mirror.omim.org/entry/606578
• UniProt: http://www.uniprot.org/uniprot/Q96PS8.html