aquaporin-1; AQP-1; aquaporin-CHIP; water channel protein for erythrocytes & kidney proximal tubule; urine water channel (AQP1, CHIP28)
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Function
- forms a water-specific channel that provides plasma membranes of red cells & kidney proximal tubules with high permeability to water, permitting water to move in the direction of an osmotic gradient
- homotetramer
Structure
- aquaporins contain two tandem repeats each containing 3 membrane-spanning domains & a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)
- belongs to the MIP/aquaporin (TC 1.A.8) family
Compartment
membrane
Expression
- expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney & pancreas
- weakly expressed in brain, placenta & liver
Polymorphism
responsible for Colton blood group system
Pharmacology
- inhibited by submillimolar concentrations of mercury
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P29972.html
- ↑ dbRBC/BGMUT; Note: Blood group antigen gene mutation database http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=colton
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/aqp1/
- ↑ Protein Spotlight; Note: Liquid states - Issue 36 of July 2003 http://www.expasy.org/spotlight/back_issues/sptlt036.shtml