ligand-gated ion channel Zn+2-activated 1; ligand-gated ion-channel receptor L2 (LGICZ1, L2, LGICZ, ZACN, ZAC)

Function

• Zn+2-activated ligand-gated ion channel

Structure

• glycosylated
• belongs to the ligand-gated ionic channel (TC 1.A.9) family

Compartment

cell membrane

Alternative splicing

named isoforms=3

Expression

• detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach & fetal brain
• in the adult brain, expression is detected in the hippocampus, striatum, amygdala & thalamus

Comparative biology

• the mouse & rat orthologous proteins do not exist

Notes

It is uncertain whether Met-1 or Met-2 is the initiator

More general terms

• glycoprotein
• ion channel
• evolutionary divergent protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3531
• UniProt: http://www.uniprot.org/uniprot/Q401N2.html