rab-10 proto-oncogene

^[1]^[2]

Function

RAB10 variants modify risk for Alzheimer's disease^[2]
- knockdown of RAB10 decreases Abeta42 & Abeta42/Abeta40 in neuroblastoma cells
- RAB10 expression is elevated in brain of patients with Alzheimer's disease
- Rs142787485 in RAB10 confers protection against Alzheimer's disease^[2]

↑ Seabra MC et al Rab GTPases, intracellular traffic and disease Trends in Molecular Medicine 8:23, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11796263
↑ ^2.0 ^2.1 ^2.2 Ridge PG, Karch CM, Hsu S et al Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. Nov 29 2017 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29183403 Free PMC Article