CD69; early activation antigen CD69; early T-cell activation antigen p60; GP32/28; Leu-23; MLR-3; EA1; BL-AC/P26; activation inducer molecule; AIM (CD69)

Function

• role in lymphocyte proliferation & functions as a signal transmitting receptor in lymphocytes, natural killer cells, & platelets
• earliest inducible cell surface glycoprotein in lymphoid activation
• constitutive Ser/Thr phosphorylation in both mature thymocytes & activated T-lymphocytes

Structure

• homodimer; disulfide-linked
• contains 1 C-type lectin domain

Compartment

• plasma membrane

Expression

• activated T cells, B cells NK cells
• neutrophils
• eosinophils
• epidermal Langerhans cells

Pathology

• expressed in T cells in rheumatoid arthritis, viral hepatitis & autoimmune thyroid disorders

More general terms

• CD antigen
• glycoprotein
• lectin

Database

• UniProt: http://www.uniprot.org/uniprot/Q07108.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=969
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:969
• OMIM: https://mirror.omim.org/entry/107273