phosphatase & actin regulator 3; scapinin; scaffold-associated PP1 inhibiting protein (PHACTR3, C20orf101, SCAPIN1)

Function

• binds actin & PPP1CA
  • inhibits protein phosphatase 1 (PP1) activity

Structure

• belongs to the phosphatase & actin regulator family
• contains 4 RPEL repeats

Compartment

• nucleus matrix
• localized to the nuclear matrix - intermediate filament scaffold
• isoform 2 is also found in some cytoplasmic extensions

Alternative splicing

named isoforms=3

Expression

• abundantly expressed in brain

Pathology

• found in several tumors such as lung carcinomas, nervous tumors & HL-60 leukemia cells
• isoform 3 is the major form in U-937, GOTO & HL-60 leukemia cells
• down-regulated in HL-60 leukemia cells by RA, PMA & dimethyl sulfoxide

More general terms

• phosphatase & actin regulator

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=116154
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:116154
• OMIM: https://mirror.omim.org/entry/608725
• UniProt: http://www.uniprot.org/uniprot/Q96KR7.html