growth/differentiation factor 9B; GDF-9B; bone morphogenetic protein 15; BMP-15 (BMP15 GDF9B)

Function

• may be involved in follicular development
• oocyte-specific growth/differentiation factor that stimulates folliculogenesis & granulosa cell (GC) growth

Structure

• homodimer. but, in contrast to other members of this family, cannot be disulfide-linked
• belongs to the TGF-beta family
• the mature protein migrates in two distinct mature proteins, P16 (16KDa) & P17 (17KDa)

Compartment

secreted

Pathology

• defects in BMP15 are the cause of
  • ovarian dysgenesis type 2
  • premature ovarian failure type 4

More general terms

• growth/differentiation factor (GDF)
• bone morphogenetic protein (BMP)
• TGF-beta family protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9210
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9210
• OMIM: https://mirror.omim.org/entry/300247
• OMIM: https://mirror.omim.org/entry/300510
• UniProt: http://www.uniprot.org/uniprot/O95972.html