B melanoma antigen 4 (BAGE4 MLL3P)

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Function

Structure

belongs to the BAGE family

Expression

  • not expressed in normal tissues except in testis

Pathology

expressed in melanoma, bladder & lung carcinomas

Genetics

  • ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene
  • the BAGE family was expanded by juxtacentromeric movement &/or acrocentric exchanges
  • BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 & 21 & of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 & 21

More general terms

References

Database