B melanoma antigen 4 (BAGE4 MLL3P)
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Function
- known, candidate gene encoding tumor antigens
Structure
belongs to the BAGE family
Expression
- not expressed in normal tissues except in testis
Pathology
expressed in melanoma, bladder & lung carcinomas
Genetics
- ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene
- the BAGE family was expanded by juxtacentromeric movement &/or acrocentric exchanges
- BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 & 21 & of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 & 21