CD228, melanotransferrin or melanoma-associated antigen p97

Function

• role in iron cellular uptake

Cofactor:

• binds a single atom of iron per subuni
• may also bind Zn+2

Compartment

• attached to the membrane by a GPI-anchor
• appears to be internalized, then recycled back to the plasma membrane

Expression

• fetal tissues
• liver, epithelium, umbilical cord, placenta, sweat gland ducts,
• capillary endothelial cells especially in brain

Pathology

• expressed in melanomas
• serum levels are increased in patients with Alzheimer's disease

More general terms

• CD antigen
• plasma membrane protein
• glycoprotein
• metalloprotein
• melanoma associated antigen (MAGE)

Database

• UniProt: http://www.uniprot.org/uniprot/P08582.html
• OMIM: https://mirror.omim.org/entry/155750
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4241