Tyrosine-protein phosphatase non-receptor type 20 (hPTPN20a, PTPN20A)

Function

• tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli
• has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates
• phosphorylated upon DNA damage, probably by ATM or ATR

protein tyrosine phosphate + H2O
              <-->
protein tyrosine + phosphate

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class subfamily
• contains 1 tyrosine-protein phosphatase domain

Compartment

• nucleus, cytoplasm
• colocalizes with microtubule-organizing center & intracellular membrane compartments

Alternative splicing

named isoforms=15

Expression

• present in many cell lines (at protein level)
• widely expressed

More general terms

• nuclear protein
• phosphoprotein
• phosphoprotein phosphatase

Database

• UniProt: http://www.uniprot.org/uniprot/Q4JDL3.html