phosphatidylinositol 4-kinase type 2-alpha (PI4K2A)

Function

• together with PI4K2B & the type 3 PI4Ks (PIK4CA &PIK4CB), contributes to the overall PI4-kinase activity of the cell
• phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of PIP2, a precursor of the second messenger InsP3
• contributes to production of InsP3 in stimulated cells

ATP + 1-phosphatidyl-1D-myo-inositol
                 <-->
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

Structure

• belongs to the PI3/PI4-kinase family, type II PI4K subfamily
• contains 1 PI3K/PI4K domain

Compartment

• cytoplasm, plasma membrane
• found in non-caveolar membrane rafts

Expression

• widely expressed
• highest expression in kidney, brain, heart, skeletal muscle, placenta
• lowest expression is observed in colon, thymus, small intestine

More general terms

• phosphoinositide-4-kinase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BTU6.html