Na+/hydrogen exchanger 7; Na+/H+ exchanger 7; NHE-7; solute carrier family 9 member 7 (SLC9A7, NHE7)

Function

• mediates electroneutral exchange of protons for Na+ & K+ across endomembranes
• may contribute to Golgi volume & cation homeostasis
• interacts with SCAMP1, SCAMP2 & SCAMP5; may play a role in its shuttling from trans-Golgi network to recycling endosomes

Structure

• belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

Compartment

• Golgi, trans-Golgi network
• recycling endosome

Expression

• ubiquitously expressed

Notes

• not inhibited by amiloride
• inhibited by benzamil & quinine

More general terms

• Na+/H+ antiporter
• transmembrane 13 protein
• solute carrier family 9 (SLC9, SLC9A)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84679
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84679
• OMIM: https://mirror.omim.org/entry/300368
• UniProt: http://www.uniprot.org/uniprot/Q96T83.html