OTU domain-containing protein 7B (zinc finger protein Cezanne, zinc finger A20 domain-containing protein 1, cellular zinc finger anti-NF-kappa B protein, OTUD7B, ZA20D1)

Function

• has deubiquitinating activity directed towards Lys-48 or Lys-63-linked polyubiquitin chains
• hydrolyzes both linear & branched forms of polyubiquitin
• negative regulator of nuclear factor NF-kappa-B
• interacts with TRAF6

Structure

• belongs to the peptidase C64 family.
• contains 1 A20-type zinc finger
  • contains 1 OTU domain

Compartment

cytoplasm, nucleus

Expression

• widely expressed, including kidney, heart, fetal liver
• higher expression in primary immature B-cells as compared to mature B-cells

More general terms

• zinc finger protein
• cysteine proteinase; thiol proteinase
• peptidase; peptide hydrolase
• phosphoprotein
• OTU domain-containing protein (OTUD)

Database

• UniProt: http://www.uniprot.org/uniprot/Q6GQQ9.html