G6b protein (G6B, C6orf25)

Function

• isoform B is a putative inhibitory receptor
• isoform A may be its activating counterpart
• interacts with PTPN6 & PTPN11

Structure

• all isoforms are N-glycosylated
• isoform E is O-glycosylated - isoform A: cell membrane - isoform B: cell membrane - isoform D: endoplasmic reticulum, Golgi - isoform E: endoplasmic reticulum, Golgi - isoforms D & E lack the transmembrane regions, thus remain in the endoplasmic reticulum &/or Golgi

Alternative splicing

named isoforms=7

Expression

expressed in a restricted set of hematopoietic cell lines

Pathology

• expressed in transformed cell lines
  • erythroleukemia cell line K562
  • T-cell leukemia cell lines Molt4 & Jurkat

More general terms

• glycoprotein
• membrane protein
• receptor
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606520
• UniProt: http://www.uniprot.org/uniprot/O95866.html