CD205; lymphocyte antigen 75; DEC-205; gp200-MR6 (LY75)

Function

• antigen endocytic receptor
• directs movement from the extracellular space to specialized antigen processing compartment
• decreases B cell proliferation

Structure

• N-glycosylated
• contains 10 C-type lectin domains
• contains 1 fibronectin F2 module
• contains 1 ricin B-type lectin domain

Compartment

membrane

Alternative splicing

named isoforms=4 Produced by intergenic splicing of LY75 & CD302

Expression

• expressed in spleen, thymus, colon & peripheral blood lymphocytes
• detected in myeloid & B lymphoid cell lines

Pathology

• isoforms 2 & 3 are expressed in Reed-sternberg cells of Hodgkin's lymphoma by a transcriptional control mechanism which cotranscribed an mRNA containing LY75 & CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins

More general terms

• CD antigen
• receptor
• glycoprotein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4065
• OMIM: https://mirror.omim.org/entry/604524
• UniProt: http://www.uniprot.org/uniprot/O60449.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4065